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KMID : 0369819930230010027
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Jorunal of Korean Pharmaceutical Sciences
1993 Volume.23 No. 1 p.27 ~ p.32
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Drug Interaction Between Phenytoin and Diltiazem in Rabbit
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최준식/Choi JS
장일효/Chang IH
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Abstract
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Pharmacokinetic drug interaction between phenytoin and diltiazem was investigated following i.v. administration concomitantly to rabbits. Diltiazem was coadministered at doses of 1, 2 and 3 mg/kg, respectively, with phenytoin (5 mg/kg) to rabbits. Plasma concentration and AUC of phenytoin were increased significantly, but volume of distribution and total body clearance were decreased significantly (p<0.05) at doses of 2 mg and 3 mg/kg of diltiazem. From the results of this experiment, it is desirable that dosage regimen of phenytoin should be adjusted and that therapeutic drug monitoring should be practiced for reduction of side or toxic effect when phenytoin should be administered with diltiazem in clinical practice.
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KEYWORD
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Pharmacokinetic interaction, Phenytoin, Diltiazem, Coadministration, Total body clearance, Distribution rate constant, Dosage regimen, Area under the curve (AUC)
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